Reproducibility Study of Computational Modelling of Glucose Uptake by SGLT1 and GLUT2 in the Enterocyte

Many researchers in the last couple of decades have suggested that glucose absorption small intestine depends on both constitutively expressed SGLT1 and translocated GLUT2 brush border membrane, especially presence a high concentration luminal glucose. Afshar et al. generated computational model non-isotonic uptake by intestinal epithelial cells. The incorporates apical via GLUT2, basolateral efflux into blood cellular volume changes response to conditions. dependence glucose, flow rate, inlet is studied, results explain more about role cell absorption. Here, we used CellML file provided authors, together with SED-ML files Python scripts, demonstrate reproduction figures original paper using associated model.